Radiobiological Outcomes, Microdosimetric Evaluations and Monte Carlo Predictions in Eye Proton Therapy

CATANA (Centro di AdroTerapia ed Applicazioni Nucleari Avanzate) was the first Italian protontherapy facility dedicated to treatment of ocular neoplastic pathologies. It is in operation at LNS Laboratories Institute for Nuclear Physics (INFN-LNS) and date, 500 patients have been successfully treated. Even though proton therapy has demonstrated success clinical settings, there still a need more accurate models because they are crucial estimation clinically relevant RBE values. Since can vary depending on several physical biological parameters, clear experimental data generate predictions. Establishing database cell survival experiments therefore useful accurately predict effects irradiations both cancerous normal tissue. The main aim this work compare values obtained from in-vitro with predictions made by LEM II (Local Effect Model), Monte Carlo approaches, semi-empirical based LET measurements. For purpose, 92.1 uveal melanoma ARPE-19 cells derived retinal pigmented epithelium were selected irradiated middle SOBP facility. remarkable results show potentiality using microdosimetric spectrum, simulations model not only but also curves.